Download A Handbook for DNA-Encoded Chemistry: Theory and by Robert A. Goodnow Jr. PDF

By Robert A. Goodnow Jr.

This ebook comprehensively describes the improvement and perform of DNA-encoded library synthesis know-how. jointly, the chapters element an method of drug discovery that gives an enticing addition to the portfolio of latest hit iteration applied sciences corresponding to high-throughput screening, structure-based drug discovery and fragment-based screening. The book:

  • Provides a helpful advisor for realizing and employing DNA-encoded combinatorial chemistry
  • Helps chemists generate and display novel chemical libraries of huge dimension and caliber
  • Bridges interdisciplinary components of DNA-encoded combinatorial chemistry – artificial and analytical chemistry, molecular biology, informatics, and biochemistry
  • Shows medicinal and pharmaceutical chemists how you can successfully expand to be had “chemical house” for drug discovery
  • Provides specialist and up to date precis of pronounced literature for DNA-encoded and DNA-directed chemistry know-how and methods

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Additional info for A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery

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2). This report drew much attention to the idea that combinatorial chemistry could produce large numbers of not just peptides and oligonucleotides, but of compounds that were among prototypical drug-like structures. An important aspect of the Ellman work was not only the type of target molecules that could be made but also the type of reactions that could be applied to the solid phase; in addition to amidations, the reaction sequence included carbonyl-amine condensations and N-alkylations. Since that time, tremendous efforts have gone into developing elegant and intricate synthetic procedures on various solid-phase supports.

Fuller, C. , Middendorf, L. , Benner, S. , Church, G. , Jovanovich, S. , Nelson, J. , Schloss, J. , Schwartz, D. , Vezenov, D. V. (2009). The challenges of sequencing by synthesis. Nat. , 27, 1013–1023. 24. Metzker, M. L. (2010). Sequencing technologies—the next generation. Nat. Rev. , 11, 31–46. 18 Just Enough Knowledge… 25. , Syed, B. A. (2013). Commercial prospects for genomic sequencing technologies. Nat. Rev. , 12, 341–342. 26. , Mermod, J. , Kawashima, E. (2000). Solid phase DNA amplification: characterization of primer attachment and amplification mechanism.

A. (2013). Commercial prospects for genomic sequencing technologies. Nat. Rev. , 12, 341–342. 26. , Mermod, J. , Kawashima, E. (2000). Solid phase DNA amplification: characterization of primer attachment and amplification mechanism. , 28, e87. 27. , Turcatti, G. (2006). BTA, a novel reagent for DNA attachment on glass and efficient generation of solid-phase amplified DNA colonies. , 34, e22. 28. , Kim, D. , Marma, M. , Edwards, J. , Turro, N. J. (2006). Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators.

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