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Oxidation of lipids modifies membranes and impairs their function. Fluidity is decreased, membrane-bound enzymes and receptors are inactivated, red blood cells are damaged and endothelial cells are injured, increasing blood vessel fragility. , 1997) and the formation of plaque (Ide and Lau, 1997). Toxic aldehydes formed in lipid oxidation react with the apoprotein B of the LDL particle to produce a novel epitome that is recognized by macrophage receptors, resulting in the formation of foam cells and atherosclerotic plaques and increased risk of heart disease and stroke (Witztum, 1993).

Cohen, M. L. (1996). Effects of oxidized low density lipoproteins on vascular contraction and relaxation: clinical and pharmacological implications in atherosclerosis. Pharmacol. Rev, 48, 3-9 34 Chidiebere E. Ugwu and Stephen M. , Maldonado, P. , Martínez- Martínez, C. M. ,(2007). Renoprotective and antihypertensive effects of S-allylcysteine in 5/6 nephrectomized rats. Am J Physiol Renal Physio,. 293, F1691-1698. & Jain, S. (2004). Effect of garlic supplementation on oxidized low density lipoproteins and lipid peroxidation in patients of essential hypertension.

A. & Goldbohm, R. A. (1996). A prospective cohort study on the relationship between onion and leek consumption, garlic supplement use and the risk of colorectal carcinoma in The Netherlands. Carcinogenesis,17, 477-484. , Abbsi, M. , Rabati, R. , Fayyaz, A. , Behnod, V. & Asgari, A. (2015). High dose of garlic extract significantly attenuated the ratio of serum LDL to HDL level in rats-fed with hypercholesterolemia diet. Diagnostic Pathology,10,74. Efendy, J. , Simmons, D. , Campbell, G. & Campbell, J.

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