By Hiroshi, MD Mitsumoto
This significant publication covers each point of dwelling with ALS, from scientific good points of the ailment to an summary of symptom administration to realizing its analysis. significant sections care for overseeing therapy and rehabilitation, residing with ALS, the disease’s complicated part, end-of-life matters, and assets. largely revised and rewritten, this version comprises new chapters at the newest methods to treating ALS indicators, using noninvasive ventilators, multidisciplinary group care, new directions being constructed by way of the yank Academy of Neurology for sufferers with ALS, using riluzole (Rilutek), and extra.
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Extra info for Amyotrophic Lateral Sclerosis: A Guide for Patients and Families, Third Edition
Drug Therapies The failure to find an effective drug therapy for ALS has not been for lack of trying. 2). Over the past several decades the treatments tested have covered the gamut from antiviral agents and antibiotics to chemotherapies, from immunomodulating agents to neurotrophic factors. What Is Amyotrophic Lateral Sclerosis? 2 Therapies Tried for Amyotrophic Lateral Sclerosis (Continued ) Neurotrophic agents Brain-derived neurotrophic factor (BDNF) Calcium channel blockers and chelating agents Calcium disodium edetate Ciliary neurotrophic factor (CNTF) Dantrolene Insulin-like growth factor (IGF-1, myotrophin) Nimodipine Xaliproden Verapamil Antimicrobial agents Other Ceftriaxone Adrenal cortex Tilerone hydrochloride Antihistaminic agents Trypan blue Trypan red Balneotherapy (natural mineral water baths) Antiviral agents Bovine gangliosides Amantadine Bromocriptine Indinavir Isoprinosine Cervico-dorsal electroshock therapy Transfer factor Guanidine Zidovudine 5-hydroxytrytophan Nutritional supplements and vitamins Hyperbaric oxygen Crude liver extract Phthalazinol Intravenous amino acids Octacosanol Snake venom (modified neurotoxin) Vitamin B1 (thiamine) Stem cells Vitamin B6 (pyridoxine) Toluloxy propanediol Penicillamine Olfactory cells Vitamin B12 “Vitamin B” in yeast preparation Probably the most ubiquitous treatment for ALS over the past century has been the antioxidant vitamin E (tocopherol).
Duchenne G. Paralysie musculaire progressive de la langue, du voile du palais et des levres. Arch Gen Med. 1860;16:283–296, 431–445. 5. Veltema AN. The case of the saltimbanque Prosper Lecomte. A contribution to the study of the history of progressive muscular atrophy (Aran-Duchenne) and amyotrophic lateral sclerosis (Charcot). Clin Neurol Neurosurg. 1975;78:204–209. 6. Charcot J-M. De la sclerose laterale amyotrophique: Symptomatologie. Prog Med. 1874;2:453–455. 7. Jean M. Charcot. In: Beighton P, Beighton G, eds.
Fasciculations are found in almost all patients with ALS, but rarely are they an initial symptom. When their presence cannot be confirmed by clinical examination, an examination called needle electromyography may be helpful to identify them. It is important to remember that fasciculations are common and occur in healthy persons, a condition that is termed benign fasciculation; in the absence of neurologic findings, such as weakness or atrophy, benign fasciculations usually have no serious clinical implications.