Download Antiviral strategies by Hans-Georg Kräusslich, Ralf Bartenschlager PDF

By Hans-Georg Kräusslich, Ralf Bartenschlager

A an important factor for antiviral treatment is the truth that all antiviral ingredients speedily decide on for resistance; hence, tracking and overcoming resistance has develop into a most vital medical paradigm of antiviral treatment. This demands wary use of antiviral medicinal drugs and implementation of mix remedies. In parallel, efforts in drug discovery need to be persisted to increase compounds with novel mode-of-action and task opposed to resistant lines. This booklet experiences the present prestige of antiviral remedy, from the roads to improvement of latest compounds to their medical use and price effectiveness. person chapters deal with in additional element all on hand drug sessions and description new ways at the moment less than development.

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1 One at a Time Traditional Synthesis . . . . . . . . . . . . . . . . . . . . 2 Parallel Synthesis . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Combinatorial Chemistry . . . . . . . . . . . . . . . . . . . . . . . . 4 High-Throughput Screening for the Identification of New HCV Leads . . . . . 5 Cell-Based Assays to Predict Toxicity and Resistance Aspects . . . . . . . . . . . 6 Pharmacokinetic and Pharmacodynamic Aspects of Drug Development of Agents for the Treatment of HCV Infections .

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26 27 28 32 32 35 37 37 39 40 40 41 42 42 43 43 44 46 Abstract Traditional methods for general drug discovery typically include evaluating random compound libraries for activity in relevant cell-free or cell-based assays. Success in antiviral development has emerged from the discovery of more focused libraries that provide clues about structure activity relationships. F. -G. Kr¨ausslich, R. F. Schinazi et al. is not enough. There are issues related to biology, toxicology, pharmacology, and metabolism that have to be addressed before a hit compound becomes nominated for clinical development.

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